ea0090p264 | Late-Breaking | ECE2023
Louise Marnet Victoria
, Hartmann Oliver
, Reissland Michaela
, Pahor Nikolett
, Landwehr Laura-Sophie
, Fassnacht Martin
, Teresa Fuss Carmina
, Elmar Diefenbacher Markus
Adrenocortical carcinoma (ACC) is a rare endocrine malignancy presenting with an incidence of 1 per million per year and an overall 5-year survival rate under 35%. Currently, curative treatment is limited to full surgical resection, while the adrenolytic drug mitotane remains the only approved medical therapy option leaving a huge demand for innovative therapeutic strategies. Genetic alterations observed in ACC commonly lead to activation of Wnt/β-Catenin signaling most f...